Publications

Neurodevelopment of Ciona robusta

Gruner HN, Pickett CJ, Bao JY,  Garcia R, Hozumi A, Scully T, Ning S, Gao M, Bautista G, Maze K, Lim K, Osugi T,  Collins-Doijode M, Cairns O, G Levis, Chen SY, Gong TX, Satake H, Moshe-Klein A, Gigante ED, Sasakura Y, Davidson B. (2025) Neural signaling contributes to heart formation and growth in the invertebrate chordate, Ciona robusta. BioRxiv, in submission. https://doi.org/10.1101/2025.04.28.651085

Gigante ED, Piekarz KM, Gurgis A, Cohen L, Razy-Krajka F, Popsuj S, Johnson CJ, Ali HS, Mohana Sundaram S, Stolfi A (2024). Specification and survival of post-metamorphic branchiomeric neurons in a non-vertebrate chordate. Development. https://doi.org/10.1242/dev.202719 

Cilia, Sonic Hedgehog, and Neurodevelopment

Terry TT, Gigante ED, Alexandre CM, Brewer KM, Engle SE, Yue X, Berbari NF, Vaisse C, Caspary T (2025). Ciliary ARL13B prevents obesity in mice. BioRxiv Preprint, in submission. DOI: 10.1101/2023.08.02.551695

RE Van Sciver, AB Long, HG Katz, Gigante ED, Caspary T (2023). Ciliary ARL13B inhibits developmental kidney cystogenesis in mouse. Developmental Biology. doi.org/10.1016/j.ydbio.2023.05.004.

Turn RE, Linnert J, Gigante ED, Wolfrum U, Caspary T, Kahn RA (2021). Roles for ELMOD2 and Rootletin in Ciliogenesis. Molecular Biology of the Cell. (PMID: 33596093)

Gigante ED and Caspary T (2021). Cilia Biology: You’re It! Tagging Proteins for Ciliary Removal. Current Biology Dispatch. (PMID: 33497637)

Gigante ED, Taylor MR, Ivanova AA, Kahn RA, Caspary T (2020). ARL13B regulates Sonic Hedgehog signaling from outside primary cilia. eLife. (PMID: 32129762)

Gigante ED and Caspary T (2020). Signaling in the primary cilium through the lens of the Hedgehog pathway. WIREs Developmental Biology. (PMID: 32084300)

Ferent J, Constable S, Gigante ED, Yam PT, Mariani LE, Legue E, Liem KF Jr, Caspary T, Charron F (2019). The Ciliary protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance. Cell Reports. (PMID: 31825820).

Gigante ED*, Long AB*, Ben-Ami J, and Caspary T. (2018) Highest Shh response disrupted in hypomorphic Smo allele with inefficient ciliary enrichment. Developmental Biology. (PMID:29571613) (* equal contribution)

Neurobiology of Addiction

Kramar CP, Castillo-Diaz F, Gigante ED, Medina JH, Barbano MF (2020). The late consolidation of an aversive memory is promoted by VTA dopamine release in the dorsal hippocampus. Eur. J. Neurosci. doi.org/10.1111/enj.15076

Gigante ED, Benaliouad F, Zamora-Olivencia V and Wise RA (2016). Optogenetic activation of a lateral hypothalamic-ventral tegmental drive-reward pathway. PLoS One (PMID:27387668)

Carter JM, Landin JD, Gigante ED, Reiger SP, Diaz MR, and Werner DF (2016) Inhibitors of calcium-activated anion channels modulate hypnotic ethanol responses in adult Sprague Dawley rats. Alcohol Clin Exp Res, (PMID:26842249)

Robinson EJ, Vardy E, DiBerto JF, Chefer VI, White KL, Fish EW, Chen M, Gigante E, Krouse MC, Sun H, Thorsell A, Roth BL, Heilig M, Malanga CJ (2015) Receptor reserve moderates mesolimbic responses to opioids in a humanized model of the OPRM1 A118G polymorphism. Neurophyschopharmacology, (PMID:25881115)

Santerre JL, Gigante ED, Landin JD, and Werner DF (2014). Molecular and behavioral characterization of adolescent protein kinase C following high dose ethanol exposure. Psychopharmacology, (PMID:24051603)

Root DH, Hoffman AF, Good CH, Zhang S, Gigante E, Lupica CR, and Morales M (2014). Norepinephrine acts at dopamine D4 receptors to depolarize neurons in the rat lateral habenula. Neuroscience, (PMID:25716845)

Gigante ED, Santerre JL, Carter JM, and Werner, DF (2014). Adolescent and adult rat cortical Protein Kinase A display divergent responses to acute ethanol exposure. Alcohol, (PMID:24874150)

Santerre JL, Rogow JA, Kolitz EB, Pal R, Landin JD, Gigante ED, and Werner DF (2014). Ethanol dose-dependently elicits opposing regulatory effects on hippocampal AMPA receptor GluA2 subunits through a zeta inhibitory peptide-sensitive kinase in adolescent and adult Sprague-Dawley rats. Neuroscience, (PMID:25218807)

Chefer VI, Bäckman CM, Gigante ED, and Shippenburg TS (2013). Kappa Opioid Receptors on Dopaminergic Neurons Are Necessary for Kappa-Mediated Place Aversion. Neuropsychopharmacology, (PMID:23921954)

Kumar S, Ren Q, Beckley JH, O’Buckley TK, Gigante ED, Santerre JL, Werner DF, and Morrow AL (2012). Ethanol Activation of Protein Kinase A Regulates GABA(A) Receptor Subunit Expression in the Cerebral Cortex and Contributes to Ethanol-Induced Hypnosis. Frontiers in Neuroscience, (PMID:22509146)

Linsenbardt DN, Moore EM, Griffin KD, Gigante ED, and Boehm SL II (2011). Tolerance to ethanol's ataxic effects and alterations in ethanol-induced locomotion following repeated binge-like ethanol intake using the DID model. Alcohol Clin Exp Res, (PMID:21410484)

Boehm SL II, Moore EM, Walsh CD, Gross CD, Cavelli AM, Gigante E, and Linsenbardt DN (2008). Using Drinking in the Dark to model prenatal binge-like exposure to ethanol in C57BL/6J mice. Dev Psychobiology (PMID:18683190)