Research
- Cancer immunology with a focus on the enhancement of natural killer cell targeting of cancer cells.
- Host-pathogen interactions.
- High-impact teaching practices for online and in-person courses.
Publications:
Marrufo, A.M., Mathew, S.O., Chaudhary, P., Malaer, J.D., Vishwanatha, J.K., Mathew, P.A. Blocking triple-negative breast cancer cell surface PCNA interaction with NKp44 enhances primary natural killer cell-mediated lysis. Am J Cancer Res, 13(3):1082-1090.
Malaer, J.D. and Mathew, P.A. Role of LLT1 and PCNA as Natural Killer Cell Immune Evasion Strategies of HCT 116 Cells. Anticancer Res, 40(12), 6613-6621. http://doi.org/10.21873/anticanres.14686
Sun, Y.*, Malaer, J.D.*, and Mathew, P.A. Lectin-like transcript 1 as a natural killer cell-mediated immunotherapeutic target for triple negative breast cancer and prostate cancer. J Cancer Metastasis Treat, 5(80), https://doi.org/10.20517/2394-4722.2019.29 (*These authors contributed equally to this work).
Malaer, J.D., Marrufo, A.M., and Mathew, P.A. 2B4 (CD244, SLAMF4) and CS1 (CD319, SLAMF7) in systemic lupus erythematosus and cancer. Clin Immunol, 204, 50-56. https://doi.org/10.1016/j.clim.2018.10.009
Marrufo, A.M., Mathew, S. O., Chaudhary, P., Malaer, J.D., Vishwanatha, J.K., and Mathew, P.A. Blocking LLT1 (CLEC2D, OCIL)-NKRP1A (CD161) interaction enhances Natural Killer cell-mediated lysis of triple-negative breast cancer cells. Am J Cancer Res, 8(6), 1050-1063. PMID: 30034942
Malaer, J.D. and Mathew, P.A. CS1 (SLAMF7, CD319) is an effective immunotherapeutic target for multiple myeloma. Am J Cancer Res. 7(8). PMID 28861320.
Gans, M.J., Malaer, J.D., and Padilla, Y. Symbiosis among Lixus scrobicollis (Coleoptera: Curculionnidae), Ambrosia trifida, and Bacillus endophyticus. Southwestern Entomologist, 39(3), 469-476. doi: 10.3958/059.039.0308
