Network-Based Model For Chlamydia Sexually Transmitted Infection
Chlamydia trachomatis (Ct) is the most commonly reported STI in the U.S. with an
estimated 1.7 million infections per year. There is a significant Ct outbreak among
African American people ages 15-25 in New Orleans, LA.
In close collaboration with Tulane School of Public Health team, we have developed
Markov Chain Monte Carlo (MCMC) Stochastic Agent-Based Model for spread of Ct over
dynamic sexual network of individuals in New Orleans to investigated various mitigation
strategies such as condom use, random screening, partner notification, and re-screening.
Left: Chlamydia epidemic spread over a sexual network. Larger nodes (person) have more neighbors (sexual partners). The infection status of each person is tracked using the Susceptible (Green) - Infectious (Red) - Susceptible (SIS) framework. Middle: The implemented Ct prevention and interventions via CheckIt! program, Right: Model prediction for the impact of CheckIt! program on the prevalence in women under different intervention coverage. Darker region gives a higher Chlamydia prevalence in women.
Publications:
- Azizi, A., Dewar, J., Qu, Z., & Mac Hyman, J. (2021). Using an agent-based sexual-network
model to analyze the impact of mitigation efforts for controlling chlamydia. Epidemics,
35, 100456.
- Qu, Z., Azizi, A., Schmidt, N., Craig-Kuhn, M. C., Stoecker, C., Mac Hyman, J., &
Kissinger, P. J. (2021). Effect of screening young men for Chlamydia trachomatis on
the rates among women: a network modelling study for high-prevalence communities.
BMJ open, 11(1), e040789
- Azizi, A., Qu, Z., Lewis, B., & Mac Hyman, J. (2021). Generating a heterosexual bipartite
network embedded in social network. Applied Network Science, 6(1), 1-16.
- Boroojeni, A. A., Dewar, J., Wu, T., & Hyman, J. M. (2017). Generating bipartite networks
with a prescribed joint degree distribution. Journal of complex networks, 5(6), 839-857
- Azizi, A., Xue, L., & Hyman, J. M. (2016). A multi-risk model for understanding the spread of chlamydia. In Mathematical and statistical modeling for emerging and Re-emerging infectious diseases (pp. 249-268). Springer, Cham.
Collaborators
James Mac Hyman (Tulane University), Zhuolin Qu (University of Texas San Antanio), Patricia Kissinger (Epidemiology, Tulane), etc.