Publications
40. "Silver Binding to Bacterial Glutaredoxins Observed by NMR." SM Bilinovich, DL Morris,
JW Prokop, JA Caporoso, A Taraboletti, N Duangjumpa, MJ Panzner, LP Shriver, and TC
Leeper (2021) Biophysica, 1(4), 59-376.
39. HA Al-Ashtal, CM Ruttom, TC Leeper, AJ Berman. "The LARP1 La-Module recognizes both
ends of TOP mRNAs" RNA Biology, 18, 248-258 (2021).
38. Kundu M, Morris DL, Cruz MA, Miyoshi T, Leeper TC, and Joy A. "Elucidating the Molecular
Interactions of Encapsulated Doxorubicin Within a Non-ionic, Thermoresponsive Polyester
Coacervate" ACS Appl. Bio Mater, 3, 4626-4634 (2020)
37. RB Khattri, DL Morris, SM Bilinovich, E Manandhar, KR Napper, JW Sweet, DA Modarelli,
TC Leeper. "Identifying Ortholog Selective Fragment Molecules for Bacterial Glutaredoxins
by NMR and Affinity Enhancement by Modification with an Acrylamide Warhead" Molecules, 25, 147 (2020).
36. Morris DL, Leeper TC, Ziegler CJ “Inhibition of lysozyme's polymerization activity
using a polymer structural mimic” Polymer Chemistry, 9: 3705-3708 (2018).
35. Cruz MA, Morris DL, Swanson JP, Kundu M, Mankoci SG, Leeper TC, Joy A "Efficient Protein
Encapsulation within Thermoresponsive Coacervate-Forming Biodegradable Polyesters"
ACS Macro Letters, 7: 477-481 (2018).
34. Morris DL, Zampino AP, Taraboletti AA, Shriver LP, Leeper TC, Ziegler CJ "Lysozyme-catalyzed
formation of a conjugated polyacetylene" Polymer Chemistry, 8: 6344-6348 (2017). - hilarious back cover feature by Dan Morris, my PhD student.
33. Taraboletti A, Walker TL, Avila R, Huang H, Caporoso J, Manandhar E, Leeper TC, Modarelli
DA, Medicetty S, and Shriver LP “Cuprizone intoxication induces cell intrinsic alterations
in oligodendrocyte metabolism independent of copper chelation” Biochemistry, 56: 1518-1528 (2017)
32. Geldenhuys WJ, Caporoso J, Leeper TC, Lee YK, Lin L, Darvesh AS, Sadana P. “Structure-activity
and in vivo evaluation of a novel lipoprotein lipase (LPL) activator.” Bioorganic & Medicinal Chemistry Letters, 27: 303-308 (2017)
31. Geldenhuys WJ, Younutas H, Morris DL, Sullivan P, Darvesh AS, Leeper, TC. “Identification
of small molecules that bind to the mitochondrial protein mitoNEET” Bioorganic & Medicinal Chemistry Letters, 26: 5350-5353 (2016)
30. Khattri RB, Morris DL, Davis CM, Bilinovich SM, Caras AJ, Panzner MJ, Debord MA, Leeper
TC “An NMR-Guided Screening Method for Selective Fragment Docking and Synthesis of
a Warhead Inhibitor.” Molecules, pii: E846 (2016).
29. Chanawanno K, Kondti V, Caporoso J, Parachuri S, Leeper TC, Herrick RS, and Ziegler
CJ “Facile rhenium–peptide conjugate synthesis using a one-pot derived Re(CO)3 reagent”
Dalton Transactions, 45: 4729-35 (2016).
28. Benson S, Boyce K, Bunker R, Collins N, Daily, K, Esway A, Gilmore G, Hartzler C,
Howard G, Kasmar N, Kennedy K, King B, Kordahi T, Mattioli T, Pugh D, Ray L, Ross
S, Torcasio M, Webber D, Morris DM, Leeper TC “Multinuclear NMR and UV-Vis spectroscopy
of site directed mutants of the diabetes drug target protein mitoNEET suggest that
folding is intimately coupled to iron-sulfur cluster formation.” Inorganic Chemistry Communications, 63: 86-92. (2016). - Featured article for a CURE!!
27. Martin M, Leeper T.L.*, and Schmidt FJ “Transactivation of large ribozymes.” Methods in Molecular Biology, 1240:57-62. (2015). *corrected as Leeper T.C. in erratum (2015; 1240: E1).
26. Prokop JW, Petri V, Shimoyama ME, Watanabe I, Caserini DE, Leeper TC, Bilinovich SM,
Jacob H, Santos R, Martins AS, Araujo FC, Reis FM, and Milsted A. “Structural libraries
of protein models for multiple species to understand evolution of the renin-angiotensin
system” General and Comparative Endocrinology, 215: 106-116 (2015).
25. Chanawanno K, Caporoso J, Kondetti V, Paruchuri SM, Leeper TC, Herrick RS, and Ziegler
CJ “Facile solid phase peptide synthesis with a Re-lysine conjugate generated via
a one-pot procedure.” Dalton Transactions, 43:11452-11455 (2014).
24. AP Zampino, FM Masters, EL Bladholm, MJ Panzner, SM Berry, Leeper TC, Ziegler CJ.
"Mercury metallation of the copper protein azurin and structural insight into possible
heavy metal reactivity." Journal of Inorganic Biochemistry, 141, 152-160 (2014)
23. Geldenhuys WJ, Leeper TC, Carroll RT. "MitoNEET as a novel drug target for mitochondrial
dysfunction." Drug Discovery Today, 19 (10), 1601-1606 (2014)
22. Bilinovich SM, Davis, CM, Morris DL, Ray LA, Prokop JW, Buchan GJ, Leeper TC. "The
C-terminal domain of SRA1p has a fold more similar to PRP18 than to an RRM and does
not directly bind to the SRA1 RNA STR7 region." Journal of Molecular Biology, 426, 1753-1765 (2014). - published back-to-back with Tom Cech's group.
21. Herrick RS, Ziegler CJ, Leeper TC. "Structure and function in organometallic•protein
complexes." Journal of Organometallic Chemistry, 751, 90-110 (2014). - 50th anniversary special issue!
20. Marhabaie M, Leeper TC, Blackledge TA. "Protein Composition Correlates with the Mechanical
Properties of Spider ( Argiope trifasciata ) Dragline Silk." Biomacromolecules. 15, 20-29 (2014).
19. Wu J, Zhao C, Hu R, Lin W, Wang Q, Zhao J, Bilinovich SM, Leeper TC, Li L, Cheung
HM, Chen S, Zheng J. "Probing the weak interaction of proteins with neutral and zwitterionic
antifouling polymers." Acta Biomaterialia, 10, 751-760 (2014).
18. Panzner MJ, Bilinovich SM, Parker JA, Bladholm EL, Ziegler CJ, Berry SM, Leeper TC.
"Isomorphic deactivation of a Pseudomonas aeruginosa oxidoreductase: The crystal structure
of Ag(I) metallated azurin at 1.7 Å." Journal of Inorganic Biochemistry, 128, 11-16 (2013)
17. Blackledge TA, Kuntner M, Marhabaie M, Leeper TC, Agnarsson I. "Biomaterial evolution
parallels behavioral innovation in the origin of orb-like spider webs." Scientific Reports, 2, 833 (2012).
16. Morris MJ, Wingate KL, Silwal J, Leeper TC, Basu S. "The porphyrin TmPyP4 unfolds
the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect
to enhance translation in eukaryotic cells." Nucleic Acids Research, 40, 4137–4145 (2012)
15. Prokop JW, Leeper TC, Duan ZH, Milsted A. "Amino acid function and docking site prediction
through combining disease variants, structure alignments, sequence alignments, and
molecular dynamics: a study of the HMG domain." BMC Bioinformatics, 13, Suppl 2:S3 (2012)
14. Panzner MJ, Bilinovich SM, Youngs WJ, Leeper TC. "Silver metallation of hen egg white
lysozyme: X-ray crystal structure and NMR studies." Chemical Communications, 47, 2479-81 (2011)
13. SL Brinkley, TC Leeper, RS Rowlett, RS Herrick, CZ Ziegler, "Re(CO)3(H2O)3+ binding
to lysozyme: structure and reactivity." Metallomics, 3, 909-916 (2011) - with cover feature designed by me!
12. TC Leeper, S Zhang, W.C Van Voorhis, PJ Myler and G Varani, "Comparative analysis
of glutaredoxin domains from bacterial opportunistic pathogens." Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67 1141-1147 (2011) - with cover feature designed by Darren Begley and me!
11. SM Bilinovich, MJ Panzner, WJ Youngs, and TC Leeper, "Poly[[{u3-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonato}silver(I)]
trihydrate]," Acta Crystallographica Section E: Structure Reports, E67, (2011)
10. Lunde BM, Reichow SL, Kim M, Suh H, TC Leeper, Yang F, Mutschler H, Buratowski S,
Meinhart A, Varani G. “Cooperative interaction of transcription termination factors
with the RNA polymerase II C-terminal domain.” Nature Structural and Molecular Biology, 17, 1195-1201 (2010)
9. TC Leeper, Qu X, Lu C, Moore C, Varani G. “Novel protein-protein contacts facilitate
mRNA 3'-processing signal recognition by Rna15 and Hrp1.” Journal of Molecular Biology, 401, 334-349 (2010).
8. A Davidson, TC Leeper, Z Athanassiou, K Patora-Komisarska, J Karn, JA Robinson and
G Varani, "Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic
peptide mimics of Tat protein." PNAS, 106, 11931-11936 (2009).
7. TC Leeper, Z Athanassiou, RL Dias, JA Robinson, G Varani, "TAR RNA recognition by
a cyclic peptidomimetic of Tat protein." Biochemistry, 44, 12362-12372 (2005).
6. TC Leeper, G Varani, "The structure of an enzyme activating fragment of human telomerase
RNA." RNA, 11, 394-403 (2005).
5. G Varani, Y Chen and TC Leeper, "NMR Studies of Protein-Nucleic Acid Interactions,"
Methods in Molecular Biology 278, 289-312 (2004).
4. N Leulliot, S Quevillon-Cheruel, M Graille, H van Tilbeurgh, TC Leeper, KS Godin,
TE Edwards, STh Sigurdsson, N Rosenkrantz, RJ Nagel, M Ares and G Varani, "A new alpha-helical
extension promotes RNA binding by the dsRBD of Rnt1p RNAse III." EMBO J. 23, 2468-2477 (2004).
3. TC Leeper, N Leulliot, and G Varani. "The solution structure of an essential stem-loop
of human telomerase RNA." Nucleic Acids Research, 31, 2614-2621 (2003)
2. TC Leeper, MB Martin, H Kim, S Cox, V Semenchenko, FJ Schmidt, SR Van Doren. "Structure
of the UGAGAU hexaloop that braces Bacillus RNase P for action." Nature Structural Biology, 9, 397-403 (2002).
1. H Kim, RR Poelling, TC Leeper, MA Meyer, FJ Schmidt. "In vitro transactivation of
Bacillus subtilisRNase P RNA." FEBS Letters, 506, 235-238 (2001).
